Adult friend fiender
On prom night, after he is being bullied yet again, he injects himself with the formula and transforms, going psycho.
Gwen Stacy dons her Spider-Woman costume and fights Peter, defeating and accidentally killing him.
Tracking the Lizard into the sewer, Spider-Woman encounters a pack of Lizard men. Gwen eventually convinces Harry that he is in the wrong and allows him to run from S.
Earth 65's Captain America, Samantha Wilson, shows up to capture the Lizards and Spider Gwen as well. Gwen saves CA from the Lizards and they part ways on good terms.
The dog of Spider-Gwen's "arch-nemesis", Bodega Bandit, is eaten by the Lizard. After an issue break from the fight, involving a story line of George Stacy conversing with Matt Murdock, Gwen resumes her fight with a now mutated Harry Osborn with the assistance of Captain America.
Gwen defeats Vulture and in the end he is put away, Murdock continuing to influence him from behind bars.